The N-myc gene product in primary retinoblastomas
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چکیده
منابع مشابه
N-myc gene product expression in neuroblastoma.
The presence and distribution of N-myc gene product were studied in 13 neuroblastomas and five ganglioneuroblastomas, using immunohistochemical techniques. Nine tumors (eight neuroblastomas and one ganglioneuroblastoma of composite type) contained neuroblastoma cells with positive nuclei for N-myc protein. Microscopic examination showed that most of the positive neuroblastoma cells seemed to be...
متن کاملComparison of the Initial Treatment Results of N-myc Positive and N-myc Negative Neuroblastoma Patients
Background: Neuroblastoma is the most common extra cranial malignant solid tumor of childhood. Various molecular and cytogenetic factors have been implicated in the pathogenesis of neuroblastoma, some of which have proven useful in predicting clinical behavior. Over expression of the oncogen N-myc, is an important indicator of prognosis. Materials and Methods: Our study was performed from 20...
متن کاملDistribution of the c‐MYC gene product in colorectal neoplasia
AIMS Recent attempts to study MYC distribution in human samples have been confounded by a lack of agreement in immunohistochemical staining between antibodies targeting the N-terminus and those targeting the C-terminus of the MYC protein. The aim of this study was to use a novel in-situ hybridization (ISH) approach to detect MYC mRNA in clinically relevant samples, and thereby determine the rel...
متن کاملEnhanced expression of the N-myc gene in Wilms' tumors.
Activation of myc-family oncogenes has been implicated in the genesis of a variety of neoplasms. In addition, these genes exhibit specific patterns of expression during murine development. We now report that N- and c-myc are differentially expressed in normal developing human renal tissues and in Wilms' tumor, a neoplasm which derives from primitive kidney cells. Twelve of 13 Wilms' tumors test...
متن کاملcomparison of the initial treatment results of n-myc positive and n-myc negative neuroblastoma patients
background: neuroblastoma is the most common extra cranial malignant solid tumor of childhood. various molecular and cytogenetic factors have been implicated in the pathogenesis of neuroblastoma, some of which have proven useful in predicting clinical behavior. over expression of the oncogen n-myc, is an important indicator of prognosis. materials and methods: our study was performed from 2004 ...
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ژورنال
عنوان ژورنال: Cancer
سال: 1989
ISSN: 0008-543X,1097-0142
DOI: 10.1002/1097-0142(19890601)63:11<2134::aid-cncr2820631111>3.0.co;2-v